[HTML][HTML] The N-terminal region of comparative gene identification-58 (CGI-58) is important for lipid droplet binding and activation of adipose triglyceride lipase
A Gruber, I Cornaciu, A Lass, M Schweiger… - Journal of Biological …, 2010 - ASBMB
In mammals, excess energy is stored in the form of triacylglycerol primarily in lipid droplets of
white adipose tissue. The first step of lipolysis (ie the mobilization of fat stores) is catalyzed
by adipose triglyceride lipase (ATGL). The enzymatic activity of ATGL is strongly enhanced
by CGI-58 (comparative gene identification-58), and the loss of either ATGL or CGI-58
function causes systemic triglyceride accumulation in humans and mice. However, the
mechanism by which CGI-58 stimulates ATGL activity is unknown. To gain insight into CGI …
white adipose tissue. The first step of lipolysis (ie the mobilization of fat stores) is catalyzed
by adipose triglyceride lipase (ATGL). The enzymatic activity of ATGL is strongly enhanced
by CGI-58 (comparative gene identification-58), and the loss of either ATGL or CGI-58
function causes systemic triglyceride accumulation in humans and mice. However, the
mechanism by which CGI-58 stimulates ATGL activity is unknown. To gain insight into CGI …
